One-step production of highly monodisperse size-controlled poly(lactic-co-glycolic acid) nanoparticles for the release of a hydrophobic model drug

Biodegradable polymeric nanoparticles are considered as promising drug delivery systems due to their high potential in tuning the release and alleviate side effects. However, particle greater than 200 nm can be detected by immune system. Thus, this paper focuses on elaboration of size-controlled poly (lactic-co-glycolic acid) smaller encapsulating a model drug. For purpose, biodegradable polymer was first solubilized ethyl acetate then dispersed into water different nanoemulsification devices: shear mixer, sonicator elongational-flow reactor micromixer. Last two devices showed capacity produce monomodal targeted size range at continuous disperse phase volume ratios. On second part, produced with micromixer were employed nanocarriers for rifampicin, hydrophobic antibiotic. These drug-loaded concentrations study effect load properties. Different techniques such dynamic light scattering, transition electron microscopy ultraviolet spectroscopy thoroughly characterize nanoparticle diameter, dispersity morphology, encapsulation efficiency vitro profile. Nanoparticles micromixer, following new pre-saturation approach, had highly diameter low 63 an 40% 5% w/v measured. Drug tests under sink conditions 44% ± 2% cumulative within 8 days.